Decreased serum DNase1-activity in patients with autoimmune liver diseases

• Main Authors: Nikolaos K. Gatselis (Author), Aigli G. Vakrakou (Author), Kalliopi Zachou (Author), Theodoros Androutsakos (Author), Kalliopi Azariadis (Author), Gregorios Hatzis (Author), Menelaos N. Manoussakis (Author), George N. Dalekos (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve pati...