Intracellular distribution and internalization pathways of guanidinylated bioresponsive poly(amido amine)s in gene delivery

• Main Authors: Jinmin Zhang (Author), Chunxi Wang (Author), Mei Lu (Author), Haonan Xing (Author), Tianzhi Yang (Author), Cuifang Cai (Author), Xiaoyun Zhao (Author), Minjie Wei (Author), Jiankun Yu (Author), Pingtian Ding (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Guanidinylated bioresponsive poly(amido amine)s polymers, CAR-CBA and CHL-CBA, were synthesized by Michael-type addition reaction between guanidine hydrochloride (CAR) or chlorhexidine (CHL) and N,N'-cystaminebisacrylamide (CBA). Previous studies have shown that both polymers had high transfect...