In Silico, In Vitro, and In Vivo Studies Indicate the Potential Use of Bolaamphiphiles for Therapeutic siRNAs Delivery

• Main Authors: Taejin Kim (Author), Kirill A. Afonin (Author), Mathias Viard (Author), Alexey Y Koyfman (Author), Selene Sparks (Author), Eliahu Heldman (Author), Sarina Grinberg (Author), Charles Linder (Author), Robert P Blumenthal (Author), Bruce A Shapiro (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Specific small interfering RNAs (siRNAs) designed to silence different oncogenic pathways can be used for cancer therapy. However, non-modified naked siRNAs have short half-lives in blood serum and encounter difficulties in crossing biological membranes due to their negative charge. These obstacles...