Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis

• Main Authors: Qiong Xie (Author), Zhaoxi Zheng (Author), Biyun Shao (Author), Wei Fu (Author), Zheng Xia (Author), Wei Li (Author), Jian Sun (Author), Wei Zheng (Author), Weiwei Zhang (Author), Wei Sheng (Author), Qihong Zhang (Author), Hongzhuan Chen (Author), Hao Wang (Author), Zhuibai Qiu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multifunctional carbamate-type acetylcholinesterase (AChE) inhibitors with anti-amyloidogenic properties like phenserine are potential therapeutic agents for Alzheimer's disease (AD). We reported here the design of new carbamates using pharmacophore model strategy to modulate both cholinesteras...