New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies

New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies

AbstractIn this article, a new series of 2-((3,5-disubstituted-2-thioxo-imidazol-1-yl)imino)acenaphthylen-1(2H)-ones were synthesized. Imidazole-2-thione with acenaphthylen-one gave a hybrid scaffold that integrated key structural elements essential for DNA damage via direct DNA intercalation and in...

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Main Authors: Asmaa H. Mohamed (Author), Mohammed B. Alshammari (Author), Ashraf A. Aly (Author), Kamal U. Sadek (Author), Akil Ahmad (Author), Eman A. Aziz (Author), Amira F. El-Yazbi (Author), Eman J. El-Agroudy (Author), Marwa E. Abdelaziz (Author)
Format: Book
Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
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