Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond

• Main Authors: Stergios Boussios (Author), Charlotte Abson (Author), Michele Moschetta (Author), Elie Rassy (Author), Afroditi Karathanasi (Author), Tahir Bhat (Author), Faisal Ghumman (Author), Matin Sheriff (Author), Nicholas Pavlidis (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Genetic complexity and DNA damage repair defects are common in different cancer types and can induce tumor-specific vulnerabilities. Poly(ADP-ribose) polymerase (PARP) inhibitors exploit defects in the DNA repair pathway through synthetic lethality and have emerged as promising anticancer t...