Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond

• Hoofdauteurs: Stergios Boussios (Auteur), Charlotte Abson (Auteur), Michele Moschetta (Auteur), Elie Rassy (Auteur), Afroditi Karathanasi (Auteur), Tahir Bhat (Auteur), Faisal Ghumman (Auteur), Matin Sheriff (Auteur), Nicholas Pavlidis (Auteur)
• Formaat: Boek
• Gepubliceerd in: Adis, Springer Healthcare, 2020-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Genetic complexity and DNA damage repair defects are common in different cancer types and can induce tumor-specific vulnerabilities. Poly(ADP-ribose) polymerase (PARP) inhibitors exploit defects in the DNA repair pathway through synthetic lethality and have emerged as promising anticancer t...