Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond

• Autori principali: Stergios Boussios (Autore), Charlotte Abson (Autore), Michele Moschetta (Autore), Elie Rassy (Autore), Afroditi Karathanasi (Autore), Tahir Bhat (Autore), Faisal Ghumman (Autore), Matin Sheriff (Autore), Nicholas Pavlidis (Autore)
• Natura: Libro
• Pubblicazione: Adis, Springer Healthcare, 2020-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Genetic complexity and DNA damage repair defects are common in different cancer types and can induce tumor-specific vulnerabilities. Poly(ADP-ribose) polymerase (PARP) inhibitors exploit defects in the DNA repair pathway through synthetic lethality and have emerged as promising anticancer t...