Morphological Change by Overexpression of D385A Dominant Negative Presenilin 1 in Human Neuroblastoma SH-SY5Y Cells

• Main Authors: Daiju Tsuchiya (Author), Yoshihisa Kitamura (Author), Kazuyuki Takata (Author), Takashi Taniguchi (Author), Kengo Uemura (Author), Hiroaki Miki (Author), Tadaomi Takenawa (Author), Shun Shimohama (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Presenilin 1 (PS1) is a multifunctional protein, and its mutations are highly related to familial Alzheimer's disease (AD). In this study, we examined the effects of PS1 overexpression on neuronal morphology using SH-SY5Y cells. Overexpression of dominant-negative D385A PS1 induced morphologica...