TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA.

• Main Authors: Mélissa Erin Khan (Author), Chloé Borde (Author), Eduardo P C Rocha (Author), Véronique Mériaux (Author), Vincent Maréchal (Author), Pedro Escoll (Author), Sophie Goyard (Author), Jean-Marc Cavaillon (Author), Bénédicte Manoury (Author), Noëlle Doyen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA sequences purified from distinct organisms, e.g. non vertebrate versus vertebrate ones, were shown to differ in their TLR9 signalling properties especially when either mouse bone marrow-derived- or human dendritic cells (DCs) are probed as target cells. Here we found that the DC-targeting immuno...