Mast Cell Degranulation Decreases Lipopolysaccharide-Induced Aortic Gene Expression and Systemic Levels of Interleukin-6 In Vivo

• Main Authors: Jason M. Springer (Author), Vineesh V. Raveendran (Author), Mingcai Zhang (Author), Ryan Funk (Author), Donald D. Smith (Author), Mehrdad Maz (Author), Kottarappat N. Dileepan (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mast cells play an important role in immunomodulation and in the maintenance of vascular integrity. Interleukin-6 (IL-6) is one of the key biomarkers and therapeutic target in systemic vasculitis. The objective of the current study is to describe the role of mast cells in arterial IL-6 homeostasis....