Pharmacometric Analysis of Intranasal and Intravenous Nalbuphine to Optimize Pain Management in Infants

• Autori principali: Miriam Pfiffner (Autore), Eva Berger-Olah (Autore), Priska Vonbach (Autore), Marc Pfister (Autore), Verena Gotta (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

ObjectivesThe objective of this pharmacometric (PMX) study was to (i) characterize population pharmacokinetics (PPK) and exposure-pain response associations following intranasal (0.1 mg/kg) or intravenous (IV, 0.05 mg/kg) administration of nalbuphine, with the goal to (ii) evaluate strategies for op...