Pharmacometric Analysis of Intranasal and Intravenous Nalbuphine to Optimize Pain Management in Infants

• Asıl Yazarlar: Miriam Pfiffner (Yazar), Eva Berger-Olah (Yazar), Priska Vonbach (Yazar), Marc Pfister (Yazar), Verena Gotta (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

ObjectivesThe objective of this pharmacometric (PMX) study was to (i) characterize population pharmacokinetics (PPK) and exposure-pain response associations following intranasal (0.1 mg/kg) or intravenous (IV, 0.05 mg/kg) administration of nalbuphine, with the goal to (ii) evaluate strategies for op...