TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status

• Main Authors: Inês Ramos Rego (Author), Daniela Silvério (Author), Maria Isabel Eufrásio (Author), Sandra Sofia Pinhanços (Author), Bruna Lopes da Costa (Author), José Teixeira (Author), Hugo Fernandes (Author), Yang Kong (Author), Yao Li (Author), Stephen H. Tsang (Author), Paulo J. Oliveira (Author), Rosa Fernandes (Author), Peter M. J. Quinn (Author), Paulo Fernando Santos (Author), António Francisco Ambrósio (Author), Celso Henrique Alves (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Age-related macular degeneration (AMD) is the leading cause of severe vision loss and blindness in elderly people worldwide. The damage to the retinal pigment epithelium (RPE) triggered by oxidative stress plays a central role in the onset and progression of AMD and results from the excessive accumu...