Dissolvable polymeric microneedles loaded with aspirin for antiplatelet aggregation

• Main Authors: Baorui Wang (Author), Suohui Zhang (Author), Guozhong Yang (Author), Zequan Zhou (Author), Mengzhen Xing (Author), Han Liu (Author), Aguo Cheng (Author), Yunhua Gao (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To reduce mucosal damage in the gastrointestinal tract caused by aspirin, we developed a dissolvable polymeric microneedle (MN) patch loaded with aspirin. Biodegradable polymers provide mechanical strength to the MNs. The MN tips punctured the cuticle of the skin and dissolved when in contact with t...