Dissolvable polymeric microneedles loaded with aspirin for antiplatelet aggregation

To reduce mucosal damage in the gastrointestinal tract caused by aspirin, we developed a dissolvable polymeric microneedle (MN) patch loaded with aspirin. Biodegradable polymers provide mechanical strength to the MNs. The MN tips punctured the cuticle of the skin and dissolved when in contact with t...

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Bibliographic Details
Main Authors: Baorui Wang (Author), Suohui Zhang (Author), Guozhong Yang (Author), Zequan Zhou (Author), Mengzhen Xing (Author), Han Liu (Author), Aguo Cheng (Author), Yunhua Gao (Author)
Format: Book
Published: Elsevier, 2023-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Baorui Wang  |e author 
700 1 0 |a Suohui Zhang  |e author 
700 1 0 |a Guozhong Yang  |e author 
700 1 0 |a Zequan Zhou  |e author 
700 1 0 |a Mengzhen Xing  |e author 
700 1 0 |a Han Liu  |e author 
700 1 0 |a Aguo Cheng  |e author 
700 1 0 |a Yunhua Gao  |e author 
245 0 0 |a Dissolvable polymeric microneedles loaded with aspirin for antiplatelet aggregation 
260 |b Elsevier,   |c 2023-01-01T00:00:00Z. 
500 |a 1818-0876 
500 |a 10.1016/j.ajps.2023.100776 
520 |a To reduce mucosal damage in the gastrointestinal tract caused by aspirin, we developed a dissolvable polymeric microneedle (MN) patch loaded with aspirin. Biodegradable polymers provide mechanical strength to the MNs. The MN tips punctured the cuticle of the skin and dissolved when in contact with the subcutaneous tissue. The aspirin in the MN patch is delivered continuously through an array of micropores created by the punctures, providing a stable plasma concentration of aspirin. The factors affecting the stability of aspirin during MNs fabrication were comprehensively analyzed, and the hydrolysis rate of aspirin in the MNs was less than 2%. Compared to oral administration, MN administration not only had a smoother plasma concentration curve but also resulted in a lower effective dose of antiplatelet aggregation. Aspirin-loaded MNs were mildly irritating to the skin, causing only slight erythema on the skin and recovery within 24 h. In summary, aspirin-loaded MNs provide a new method to reduce gastrointestinal adverse effects in patients requiring aspirin regularly. 
546 |a EN 
690 |a Aspirin 
690 |a Transdermal drug delivery 
690 |a Polymeric microneedles 
690 |a Hydrolysis 
690 |a Antiplatelet aggregation 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Asian Journal of Pharmaceutical Sciences, Vol 18, Iss 1, Pp 100776- (2023) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S181808762300003X 
787 0 |n https://doaj.org/toc/1818-0876 
856 4 1 |u https://doaj.org/article/d88ce4c0222d47d2bc9f13dfcf8ad172  |z Connect to this object online.