A scalable, clinically severe pig model for Duchenne muscular dystrophy

• Main Authors: Michael Stirm (Author), Lina Marie Fonteyne (Author), Bachuki Shashikadze (Author), Magdalena Lindner (Author), Maila Chirivi (Author), Andreas Lange (Author), Clara Kaufhold (Author), Christian Mayer (Author), Ivica Medugorac (Author), Barbara Kessler (Author), Mayuko Kurome (Author), Valeri Zakhartchenko (Author), Arne Hinrichs (Author), Elisabeth Kemter (Author), Sabine Krause (Author), Rüdiger Wanke (Author), Georg J. Arnold (Author), Gerhard Wess (Author), Hiroshi Nagashima (Author), Martin Hrabĕ de Angelis (Author), Florian Flenkenthaler (Author), Levin Arne Kobelke (Author), Claudia Bearzi (Author), Roberto Rizzi (Author), Andrea Bähr (Author), Sven Reese (Author), Kaspar Matiasek (Author), Maggie C. Walter (Author), Christian Kupatt (Author), Sibylle Ziegler (Author), Peter Bartenstein (Author), Thomas Fröhlich (Author), Nikolai Klymiuk (Author), Andreas Blutke (Author), Eckhard Wolf (Author)
• Format: Book
• Published: The Company of Biologists, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Large-animal models for Duchenne muscular dystrophy (DMD) are crucial for the evaluation of diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 (DMDΔ52) exhibit molecular, clinical and pathological hallmarks of DMD, but die before sexual maturity and canno...