The Spinal Muscarinic M1 Receptors and GABAA Receptors Contribute to the McN-A-343-Induced Antinociceptive Effects During Thermal Stimulation of Mice

• Main Authors: Kenji Honda (Author), Keigo Horikawa (Author), Suguru Ando (Author), Kohei Koga (Author), Satoshi Kawata (Author), Keisuke Migita (Author), Yukio Takano (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study was undertaken to clarify how spinal muscarinic receptors are involved in the antinociceptive effects in thermal stimulation. Intrathecal (i.t.) injection of the muscarinic agonist McN-A-343 inhibited the tail-flick response to noxious thermal stimulation in a dose-dependent manner...