A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression

• Main Authors: Zijun Zhou (Author), Xiaoming Li (Author), Zhiqing Liu (Author), Lixun Huang (Author), Yuying Yao (Author), Liuyou Li (Author), Jian Chen (Author), Rongxin Zhang (Author), Jia Zhou (Author), Lijing Wang (Author), Qian-Qian Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiogenesis dysregulation contributes to inflammation, infections, immune disorders, and carcinogenesis. Bromodomain-containing protein 4 (BRD4) is an epigenetic reader that recognizes histone proteins and acts as a transcriptional regulator to trigger tumor growth and the inflammatory response. Th...