Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations

• Main Authors: Lucia Mora-Jimenez (Author), Miguel Valencia (Author), Rocio Sanchez-Carpintero (Author), Jan Tønnesen (Author), Saja Fadila (Author), Moran Rubinstein (Author), Manuela Gonzalez-Aparicio (Author), Maria Bunuales (Author), Eva Fernandez-Pierola (Author), Maria Jesus Nicolas (Author), Elena Puerta (Author), Cristina Miguelez (Author), Paula Gimenez Minguez (Author), Sara Lumbreras (Author), Gloria Gonzalez-Aseguinolaza (Author), Ana Ricobaraza (Author), Ruben Hernandez-Alcoceba (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dravet syndrome is a genetic encephalopathy characterized by severe epilepsy combined with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only partial control of seizures and provide little benefit on the patient's neurological development. In >80% of cas...