Targeting MyD88 Downregulates Inflammatory Mediators and Pathogenic Processes in PBMC From DMARDs-Naïve Rheumatoid Arthritis Patients

• Egile Nagusiak: Sergio Ramirez-Perez (Egilea), Edith Oregon-Romero (Egilea), Itzel Viridiana Reyes-Perez (Egilea), Pallavi Bhattaram (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

MyD88-dependent intracellular signalling cascades and subsequently NF-kappaB-mediated transcription lead to the dynamic inflammatory processes underlying the pathogenesis of rheumatoid arthritis (RA) and related autoimmune diseases. This study aimed to identify the effect of the MyD88 dimerization i...