GLP-1 Analog Liraglutide Improves Vascular Function in Polymicrobial Sepsis by Reduction of Oxidative Stress and Inflammation

• Main Authors: Johanna Helmstädter (Author), Karin Keppeler (Author), Franziska Aust (Author), Leonie Küster (Author), Katie Frenis (Author), Konstantina Filippou (Author), Ksenija Vujacic-Mirski (Author), Simeon Tsohataridis (Author), Sanela Kalinovic (Author), Swenja Kröller-Schön (Author), Matthias Oelze (Author), Markus Bosmann (Author), Thomas Münzel (Author), Andreas Daiber (Author), Sebastian Steven (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis causes high mortality in the setting of septic shock. LEADER and other trials revealed cardioprotective and anti-inflammatory properties of glucagon-like peptide-1 (GLP-1) analogs like liraglutide (Lira). We previously demonstrated improved survival in lipopolysaccharide (LPS)-induced endotox...