Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ADAM17 gene expression during <it>in vitro </it>maturation of porcine COCs

• Những tác giả chính: Yamashita Yasuhisa (Tác giả), Hishinuma Mitsugu (Tác giả), Shimada Masayuki (Tác giả)
• Định dạng: Sách
• Được phát hành: BMC, 2009-12-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

<p>Abstract</p> <p>Objectives</p> <p>During ovulation, it has been shown that LH stimulus induces the expression of numerous genes via PKA, p38 MAPK, PI3K and ERK1/2 in cumulus cells and granulosa cells. Our recent study showed that EGF-like factor and its protease (TAC...