Study on the Neuroprotective, Radical-Scavenging and MAO-B Inhibiting Properties of New Benzimidazole Arylhydrazones as Potential Multi-Target Drugs for the Treatment of Parkinson's Disease

• Main Authors: Neda Anastassova (Author), Denitsa Aluani (Author), Nadya Hristova-Avakumova (Author), Virginia Tzankova (Author), Magdalena Kondeva-Burdina (Author), Miroslav Rangelov (Author), Nadezhda Todorova (Author), Denitsa Yancheva (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress is a key contributing factor in the complex degenerating cascade in Parkinson's disease. The inhibition of MAO-B affords higher dopamine bioavailability and stops ROS formation. The incorporation of hydroxy and methoxy groups in the arylhydrazone moiety of a new series of 1,3-d...