Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

• Главные авторы: Chao Wang (Автор), Juan Diez (Автор), Hajeung Park (Автор), Christoph Becker-Pauly (Автор), Gregg B. Fields (Автор), Timothy P. Spicer (Автор), Louis D. Scampavia (Автор), Dmitriy Minond (Автор), Thomas D. Bannister (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2021-02-01T00:00:00Z.
• Предметы: article
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Meprin α is a zinc metalloproteinase (metzincin) that has been implicated in multiple diseases, including fibrosis and cancers. It has proven difficult to find small molecules that are capable of selectively inhibiting meprin α, or its close relative meprin β, over numerous other metzincins which, i...