Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

• Hauptverfasser: Chao Wang (Verfasst von), Juan Diez (Verfasst von), Hajeung Park (Verfasst von), Christoph Becker-Pauly (Verfasst von), Gregg B. Fields (Verfasst von), Timothy P. Spicer (Verfasst von), Louis D. Scampavia (Verfasst von), Dmitriy Minond (Verfasst von), Thomas D. Bannister (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2021-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Meprin α is a zinc metalloproteinase (metzincin) that has been implicated in multiple diseases, including fibrosis and cancers. It has proven difficult to find small molecules that are capable of selectively inhibiting meprin α, or its close relative meprin β, over numerous other metzincins which, i...