The volume regulated anion channel VRAC regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria function

• Main Authors: Xiaoyan Wu (Author), Xin Yi (Author), Boxin Zhao (Author), Yuanxing Zhi (Author), Ziwei Xu (Author), Ying Cao (Author), Xiong Cao (Author), Jianxin Pang (Author), Ken Kin Lam Yung (Author), Shiqing Zhang (Author), Shuwen Liu (Author), Pingzheng Zhou (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The NLRP3 inflammasome is a supramolecular complex that is linked to sterile and pathogen-dependent inflammation, and its excessive activation underlies many diseases. Ion flux disturbance and cell volume regulation are both reported to mediate NLRP3 inflammasome activation, but the underlying orche...