Effects of the selective AMPA modulator NBI‐1065845 on the pharmacokinetics of midazolam or ethinyl estradiol-levonorgestrel in healthy adults

• Main Authors: Swan Lin (Author), Adrian Ionescu (Author), Jessica Maynard‐Scott (Author), Mike Kennedy (Author), David P. Walling (Author), Maura Furey (Author), Jaskaran B. Singh (Author)
• Format: Book
• Published: Wiley, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This parallel‐arm, phase I study investigated the potential cytochrome P450 (CYP)3A induction effect of NBI‐1065845 (TAK‐653), an investigational α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor potentiator in phase II development for major depressive disorder. The midazolam tr...