9-cis-retinoic acid signaling in Sertoli cells regulates their immunomodulatory function to control lymphocyte physiology and Treg differentiation

• Main Authors: Alicja Kamińska (Author), Laura Pardyak (Author), Sylwia Lustofin (Author), Karolina Gielata (Author), Zbigniew Arent (Author), Agnieszka Pietsch-Fulbiszewska (Author), Anna Hejmej (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Testis is an immune privileged organ, which prevents the immune response against sperm antigens and inflammation. Testicular cells responsible for immune tolerance are mainly Sertoli cells, which form the blood-testis barrier and produce immunosuppressive factors. Sertoli cells p...