Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats

• Main Authors: Priscilla Kolibea Mante (Author), Kweku Abakah-Ewusi (Author), Amanda Adoley Mingle (Author), Mustapha Seidu Kpienaan (Author), Samuel Offei-Twum (Author), Nana Kofi Kusi-Boadum (Author), Nana Ofori Adomako (Author), Newman Osafo (Author)
• Format: Book
• Published: Faculty of Pharmacy, Mahidol University, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Traditionally, Xylopia aethiopica is used to manage pain disorders such as neuralgia, colic pain, rheumatism and headache. Using animal models, this study aimed to investigate the ability of Xylopic Acid (XA), a kaurene diterpene obtained from Xylopia aethiopica, to cause tolerance when administered...