Defining the Optimal Selenium Dose for Prostate Cancer Risk Reduction: Insights from the U-Shaped Relationship between Selenium Status, DNA Damage, and Apoptosis

• Main Authors: Emily C. Chiang (Author), Shuren Shen (Author), Seema S. Kengeri (Author), Huiping Xu (Author), Gerald F. Combs (Author), J. Steven Morris (Author), David G. Bostwick (Author), David J. Waters (Author)
• Format: Book
• Published: SAGE Publishing, 2010-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our work in dogs has revealed a U-shaped dose response between selenium status and prostatic DNA damage that remarkably parallels the relationship between dietary selenium and prostate cancer risk in men, suggesting that more selenium is not necessarily better. Herein, we extend this canine work to...