Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration

• Main Authors: Fernando Cruz-Guilloty (Author), Ali M. Saeed (Author), Jose J. Echegaray (Author), Stephanie Duffort (Author), Asha Ballmick (Author), Yaohong Tan (Author), Michel Betancourt (Author), Eduardo Viteri (Author), Ghansham C. Ramkhellawan (Author), Eric Ewald (Author), William Feuer (Author), DeQiang Huang (Author), Rong Wen (Author), Li Hong (Author), Hua Wang (Author), James M. Laird (Author), Abdoulaye Sene (Author), Rajendra S. Apte (Author), Robert G. Salomon (Author), Joe G. Hollyfield (Author), Victor L. Perez (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Age-related macular degeneration (AMD) is a major cause of blindness in the developed world. Oxidative stress and inflammation are implicated in AMD, but precise mechanisms remain poorly defined. Carboxyethylpyrrole (CEP) is an AMD-associated lipid peroxidation product. We previously demonstrated th...