Calycosin pretreatment enhanced the therapeutic efficacy of mesenchymal stem cells to alleviate unilateral ureteral obstruction-induced renal fibrosis by inhibiting necroptosis

• Main Authors: Qiongdan Hu (Author), Bingwen Zhu (Author), Guoqiang Yang (Author), Jian Jia (Author), Honglian Wang (Author), Ruizhi Tan (Author), Qiong Zhang (Author), Li Wang (Author), Fahsai Kantawong (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone marrow-derived mesenchymal stem cells (MSCs) show antifibrotic activity in various chronic kidney diseases. Here, we aimed to investigate whether Calycosin (CA), a phytoestrogen, could enhance the antifibrotic activity of MSCs in primary tubular epithelial cells (PTECs) induced by TGF-β1 and in...