In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis.

• Main Authors: Elmarie Myburgh (Author), Jonathan A Coles (Author), Ryan Ritchie (Author), Peter G E Kennedy (Author), Alex P McLatchie (Author), Jean Rodgers (Author), Martin C Taylor (Author), Michael P Barrett (Author), James M Brewer (Author), Jeremy C Mottram (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HUMAN AFRICAN TRYPANOSOMIASIS (HAT) MANIFESTS IN TWO STAGES OF DISEASE: firstly, haemolymphatic, and secondly, an encephalitic phase involving the central nervous system (CNS). New drugs to treat the second-stage disease are urgently needed, yet testing of novel drug candidates is a slow process bec...