Sesamin ameliorates nonalcoholic steatohepatitis through inhibiting hepatocyte pyroptosis in vivo and in vitro

• Main Authors: Teng Zhang (Author), Yong Zhou (Author), Yan Zhang (Author), De-Guo Wang (Author), Qiu-Yue Lv (Author), Wen Wang (Author), Ya-Ping Bai (Author), Qiang Hua (Author), Li-Qun Guo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sesamin (Ses) is a natural lignan abundantly present in sesame and sesame oil. Pyroptosis, a newly identified type of pro-inflammatory programmed necrosis, contributes to the development of non-alcoholic steatohepatitis (NASH) when hepatocyte pyroptosis is excessive. In this study, Ses treatment dem...