Discovery of New Potent anti-MERS CoV Fusion Inhibitors

• Hlavní autoři: Mahmoud Kandeel (Autor), Mizuki Yamamoto (Autor), Byoung Kwon Park (Autor), Abdulla Al-Taher (Autor), Aya Watanabe (Autor), Jin Gohda (Autor), Yasushi Kawaguchi (Autor), Kentaro Oh-hashi (Autor), Hyung-Joo Kwon (Autor), Jun-ichiro Inoue (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through competition with heptad repeat domain 2 (HR2) at its...