Discovery of New Potent anti-MERS CoV Fusion Inhibitors

• Hauptverfasser: Mahmoud Kandeel (Verfasst von), Mizuki Yamamoto (Verfasst von), Byoung Kwon Park (Verfasst von), Abdulla Al-Taher (Verfasst von), Aya Watanabe (Verfasst von), Jin Gohda (Verfasst von), Yasushi Kawaguchi (Verfasst von), Kentaro Oh-hashi (Verfasst von), Hyung-Joo Kwon (Verfasst von), Jun-ichiro Inoue (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through competition with heptad repeat domain 2 (HR2) at its...