Discovery of New Potent anti-MERS CoV Fusion Inhibitors

• Autori principali: Mahmoud Kandeel (Autore), Mizuki Yamamoto (Autore), Byoung Kwon Park (Autore), Abdulla Al-Taher (Autore), Aya Watanabe (Autore), Jin Gohda (Autore), Yasushi Kawaguchi (Autore), Kentaro Oh-hashi (Autore), Hyung-Joo Kwon (Autore), Jun-ichiro Inoue (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through competition with heptad repeat domain 2 (HR2) at its...