Carvedilol Attenuates Inflammatory-Mediated Cardiotoxicity in Daunorubicin-Induced Rats

• Main Authors: Punniyakoti T. Veeravedu (Author), Makoto Kodama (Author), Vivian Soetikno (Author), Kenji Suzuki (Author), Rajarajan A. Thandavarayan (Author), Kenichi Watanabe (Author), Flori R. Sari (Author), Wawaimuli Arozal (Author), Somasundaram Arumugam (Author), Meilei Harima (Author)
• Format: Book
• Published: MDPI AG, 2011-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiotoxicity, which results from intense cardiac oxidative stress and inflammation, is the main limiting factor of the anthracyclines. Carvedilol, a beta blocker that is used as a multifunctional neurohormonal antagonist, has been shown to act not only as an anti-oxidant, but also as an anti-infla...