Spray-Dried Inhalable Powder Formulations of Gentamicin Designed for Pneumonic Plague Therapy in a Mouse Model

• Main Authors: Menghuan Zhu (Author), Dongna Zhang (Author), Lili Zhang (Author), Liangliang Zhao (Author), Likun Xu (Author), Baogang Wang (Author), Xinyu Zhang (Author), Jinwei Chen (Author), Zhuchun Bei (Author), Hong Wang (Author), Dongsheng Zhou (Author), Wenhui Yang (Author), Yabin Song (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infection with Yersinia pestis (<i>Y. pestis</i>) may cause pneumonic plague, which is inevitably fatal without treatment. Gentamicin (GM), an aminoglycoside antibiotic, is a drug commonly used in the treatment of plague. However, it requires repeated intramuscular or intravenous adminis...