Nucleoside-Lipid-Based Nanoparticles for Phenazine Delivery: A New Therapeutic Strategy to Disrupt Hsp27-eIF4E Interaction in Castration Resistant Prostate Cancer

• Автори: Hajer Ziouziou (Автор), Clément Paris (Автор), Sébastien Benizri (Автор), Thi Khanh Le (Автор), Claudia Andrieu (Автор), Dang Tan Nguyen (Автор), Ananda Appavoo (Автор), David Taïeb (Автор), Frédéric Brunel (Автор), Ridha Oueslati (Автор), Olivier Siri (Автор), Michel Camplo (Автор), Philippe Barthélémy (Автор), Palma Rocchi (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2021-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Heat shock protein 27 (Hsp27) has an established role in tumor progression and chemo-resistance of castration-resistant prostate cancer (CRPC). Hsp27 protects eukaryotic translation initiation factor 4E (eIF4E) from degradation, thereby maintaining survival during treatment. Phenazine derivative com...