Nucleoside-Lipid-Based Nanoparticles for Phenazine Delivery: A New Therapeutic Strategy to Disrupt Hsp27-eIF4E Interaction in Castration Resistant Prostate Cancer

• Main Authors: Hajer Ziouziou (Author), Clément Paris (Author), Sébastien Benizri (Author), Thi Khanh Le (Author), Claudia Andrieu (Author), Dang Tan Nguyen (Author), Ananda Appavoo (Author), David Taïeb (Author), Frédéric Brunel (Author), Ridha Oueslati (Author), Olivier Siri (Author), Michel Camplo (Author), Philippe Barthélémy (Author), Palma Rocchi (Author)
• Format: Bog
• Udgivet: MDPI AG, 2021-04-01T00:00:00Z.
• Fag: article
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Heat shock protein 27 (Hsp27) has an established role in tumor progression and chemo-resistance of castration-resistant prostate cancer (CRPC). Hsp27 protects eukaryotic translation initiation factor 4E (eIF4E) from degradation, thereby maintaining survival during treatment. Phenazine derivative com...