Novel Coumarin Derivatives as Potential Urease Inhibitors for Kidney Stone Prevention and Antiulcer Therapy: From Synthesis to In Vivo Evaluation

• Main Authors: Kiran Shahzadi (Author), Syed Majid Bukhari (Author), Asma Zaidi (Author), Tanveer A. Wani (Author), Muhammad Saeed Jan (Author), Seema Zargar (Author), Umer Rashid (Author), Umar Farooq (Author), Aneela Khushal (Author), Sara Khan (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The presence of ammonium ions in urine, along with basic pH in the presence of urease-producing bacteria, promotes the production of struvite stones. This causes renal malfunction, which is manifested by symptoms such as fever, nausea, vomiting, and blood in the urine. The involvement of urease in s...