Phytic acid attenuates acetaminophen-induced hepatotoxicity via modulating iron-mediated oxidative stress and SIRT-1 expression in mice

• Main Authors: Hend M. Hassan (Author), Nehal H. M. Abdel-Halim (Author), Ibrahim El-Shenbaby (Author), Manar A. Helmy (Author), Maha O. Hammad (Author), Ola A. Habotta (Author), Eman M. El Nashar (Author), Mansour A. Alghamdi (Author), Rashid A. Aldahhan (Author), Khulood M. Al-Khater (Author), Basmah Almohaywi (Author), Eman A. E. Farrag (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Administration of high doses of acetaminophen (APAP) results in liver injury. Oxidative stress and iron overload play roles in the pathogenesis of APAP-induced hepatotoxicity. The present study assessed the potential hepatoprotective effects of phytic acid (PA), a natural antioxidant a...