GSK5182, 4-Hydroxytamoxifen Analog, a New Potential Therapeutic Drug for Osteoarthritis

• Main Authors: Yunhui Min (Author), Dahye Kim (Author), Godagama Gamaarachchige Dinesh Suminda (Author), Xiangyu Zhao (Author), Mangeun Kim (Author), Yaping Zhao (Author), Young-Ok Son (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Estrogen-related receptors (ERRs) are the first identified orphan nuclear receptors. The ERR family consists of ERRα, ERRβ, and ERRγ, regulating diverse isoform-specific functions. We have reported the importance of ERRγ in osteoarthritis (OA) pathogenesis. However, therapeutic approaches with ERRγ...