Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L

• Main Authors: Adrien Labriet (Author), Elena De Mattia (Author), Erika Cecchin (Author), Éric Lévesque (Author), Derek Jonker (Author), Félix Couture (Author), Angela Buonadonna (Author), Mario D'Andrea (Author), Lyne Villeneuve (Author), Giuseppe Toffoli (Author), Chantal Guillemette (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including detoxification processes. We examined whether HNF1A polymorphisms are associated with clinical outcomes in two independent cohorts combining 417 Eur...