Structure-based development of potent and selective type-II kinase inhibitors of RIPK1

• Asıl Yazarlar: Ying Qin (Yazar), Dekang Li (Yazar), Chunting Qi (Yazar), Huaijiang Xiang (Yazar), Huyan Meng (Yazar), Jingli Liu (Yazar), Shaoqing Zhou (Yazar), Xinyu Gong (Yazar), Ying Li (Yazar), Guifang Xu (Yazar), Rui Zu (Yazar), Hang Xie (Yazar), Yechun Xu (Yazar), Gang Xu (Yazar), Zheng Zhang (Yazar), Shi Chen (Yazar), Lifeng Pan (Yazar), Li Tan (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2024-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases. A number of allosteric RIPK1 inhibitors (RIPK1i) have been developed, and some of them have alre...