New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3<i>H</i>)-benzothiazolones

• Main Authors: Gjorgji Atanasov (Author), Rusi I. Rusew (Author), Vladimir M. Gelev (Author), Christo D. Chanev (Author), Rosica Nikolova (Author), Boris L. Shivachev (Author), Ognyan I. Petrov (Author), Margarita D. Apostolova (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here, we describe the synthesis, characterization, and biological activities of a series of 26 new styryl-2(3H)-benzothiazolone analogs of combretastatin-A4 (CA-4). The cytotoxic activities of these compounds were tested in several cell lines (EA.hy926, A549, BEAS-2B, MDA-MB-231, HT-29, MCF-7, and M...