Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism

• Main Authors: Yu Wang (Author), Quan Zhou (Author), Huihui Wang (Author), Wei Song (Author), Jianfeng Wang (Author), Abdullah Al Mamun (Author), Peiwu Geng (Author), Yunfang Zhou (Author), Shuanghu Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work aimed to explore the mechanisms underlying the interaction of the active furanocoumarins in P. corylifolia on tofacitinib both in vivo and in vitro. The concentration of tofacitinib and its metabolite M8 was determined using UPLC-MS/MS. The peak area ratio of M8 to tofacitinib was calculat...