The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles

• Main Authors: Yunlu Jiang (Author), Maocai Yan (Author), Chunmei Wang (Author), Qinqin Wang (Author), Xiaoyu Chen (Author), Rumin Zhang (Author), Lei Wan (Author), Bingyuan Ji (Author), Bo Dong (Author), Huiyun Wang (Author), Jing Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function. We investigated the effects of Apelin-13, pGlu1-apelin-13, Apelin-17, Apeli...