Antiviral activity of ciclesonide acetal derivatives blocking SARS-CoV-2 RNA replication

• Hoofdauteurs: Genichiro Tsuji (Auteur), Shogo Nakajima (Auteur), Koichi Watashi (Auteur), Shiho Torii (Auteur), Rigel Suzuki (Auteur), Takasuke Fukuhara (Auteur), Nobumichi Ohoka (Auteur), Takao Inoue (Auteur), Yosuke Demizu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2022-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Ciclesonide (Cic) is approved as an inhalant for asthma and was clinically tested as a candidate therapy for coronavirus disease 2019 (COVID-19). Its active metabolite Cic2 was recently reported to suppress genomic RNA replication of severe acute respiratory syndrome coronavirus 2. In this study, we...