Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

• Main Authors: Víctor M Castillo-Acosta (Author), Luis M Ruiz-Pérez (Author), Els J M Van Damme (Author), Jan Balzarini (Author), Dolores González-Pacanowska (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma brucei variant surface glycoproteins (VSG) are glycosylated by both paucimannose and oligomannose structures which are involved in the formation of a protective barrier against the immune system. Here, we report that the stinging nettle lectin (UDA), with predominant N-acetylglucosamine-...