Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells

Emerging evidence suggests that the intracellular clearance system plays a vital role in maintaining homeostasis and in regulating oxidative stress and inflammation in retinal pigment epithelium (RPE) cells. Dysfunctional proteasomes and autophagy in RPE cells have been associated with the pathogene...

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Principais autores: Iswariyaraja Sridevi Gurubaran (Autor), Maria Hytti (Autor), Kai Kaarniranta (Autor), Anu Kauppinen (Autor)
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Publicado em: MDPI AG, 2022-06-01T00:00:00Z.
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3rd Floor Main Library

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