NRF2 Mediates Cellular Resistance to Transformation, Radiation, and Inflammation in Mice

• Main Authors: Dörthe Schaue (Author), Ewa D. Micewicz (Author), Josephine A. Ratikan (Author), Keisuke S. Iwamoto (Author), Erina Vlashi (Author), J. Tyson McDonald (Author), William H. McBride (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nuclear factor erythroid 2-related factor 2 (NRF2) is recognized as a master transcription factor that regulates expression of numerous detoxifying and antioxidant cytoprotective genes. In fact, models of NRF2 deficiency indicate roles not only in redox regulation, but also in metabolism, inflammato...