Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice

• Main Authors: Ilaria Morella (Author), Veronika Pohořalá (Author), Claudia Calpe-López (Author), Riccardo Brambilla (Author), Rainer Spanagel (Author), Rick E. Bernardi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ras/Raf/MEK/ERK (Ras-ERK) signaling has been demonstrated to play a role in the effects of drugs of abuse such as cocaine and alcohol, but has not been extensively examined in nicotine-related reward behaviors. We examined the role of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2), an upstream...